APPLE 2023

DAILY PROGRAM

ROOM AB (Grand Ballroom 1+2)
ROOM C (Grand Ballroom 3)
ROOM D (Orchid)
ROOM E (Chrysanthemum)

ROOM1 (Iris)
ROOM 2 (Camelia)
ROOM 3 (Lotus)

08:30-10:00

Session 1. Surveillance and Imaging Diagnosis for HCC

Morris Sherman (Univ. Health Network, Toronto), Kwan Sik Lee (CHA Univ., Seongnam), Kengo Yoshimitsu (Fukuoka Univ., Fukuoka)

08:30-08:50
Screening for HCC: From Here to Where?

Morris Sherman (Univ. Health Network, Toronto)

08:50-09:10
Emerging Imaging Tools for HCC Surveillance: Benefits and Concerns

Kengo Yoshimitsu (Fukuoka Univ., Fukuoka)

09:10-09:30
Diagnostic Strategy and Risk Stratification of Borderline Nodules on Imaging: Emphasis on OATP Transporters,
Hemodynamic Changes, and Advanced Imaging Techniques

Jeong Min Lee (Seoul National Univ., Seoul)

09:30-09:50
Developing Biomarkers for Early Detection of HCC

Stephen Lam Chan (The Chinese Univ. of Hong Kong, Hong Kong)

09:50-10:00
Discussion

10:00-10:10
Coffee Break

10:10-10:20
Opening Ceremony

10:20-10:50
State-of-the-Art Lecture 1

Takamichi Murakami (Kobe Univ., Kobe)

10:20-10:50
When We Should Consider the Biopsy for Diagnosis, Subtyping, and Prognostication of Primary Liver Cancer: Radiologist’s Perspective

Kathryn J. Fowler (Univ. of California San Diego, San Diego)

11:00-12:30

Session 2. Evolving Management of Early HCC

Pierce Chow (National Cancer Centre Singapore, Singapore), Seung Kew Yoon (The Catholic Univ. of Korea, Seoul), Yoon Jun Kim (Seoul National Univ., Seoul)

11:00-11:20
Advances in Surgical Management and Evolving Techniques

Pierce Chow (National Cancer Centre Singapore, Singapore)

11:20-11:40
Local Ablation: What's New in 2023?

Hyunchul Rhim (Sungkyunkwan Univ., Seoul)

11:40-12:00
Ablative Radiotherapy for Early HCC

Jason Chia-Hsien Cheng (National Taiwan Univ., Taipei)

12:00-12:20
Role of Transarterial Therapy in Early HCC

Hyo-Cheol Kim (Seoul National Univ., Seoul)

12:20-12:30
Discussion

12:30-13:30
Luncheon Symposium 1 [Roche] Invitation ->

13:30-14:00
Presidential Lecture Kyung-Suk Suh (Seoul National Univ., Seoul)

13:30-14:00
Evolution of APPLE and Liver Cancer Management

Norihiro Kokudo (National Center for Global Health and Medicine, Tokyo)

14:00-15:30

Session 3. New Trends in Management of Intermediate-Stage HCC

Fabio Piscaglia (Univ. of Bologna, Bologna), Masatoshi Kudo (Kindai Univ., Osaka), Jong Young Choi (The Catholic Univ. of Korea, Seoul)

14:00-14:20
Looking into the Intermediate-Stage HCC: Ongoing Effort towards Creating a Subclassification

Fabio Piscaglia (Univ. of Bologna, Bologna)

14:20-14:40
Expanding the Role of Surgical Resection and Transplantation in Intermediate-Stage HCC

Jongman Kim (Sungkyunkwan Univ., Seoul)

14:40-15:00
To What Extent Can TARE Replace the Role of TACE in the Intermediate-Stage HCC?

Edward Kim (Icahn School of Medicine at Mount Sinai, New York)

15:00-15:20
The Potential Role of Systemic Therapy in Intermediate-Stage HCC: A Paradigm Shift?

Masatoshi Kudo (Kindai Univ., Osaka)

15:20-15:30
Discussion

15:30-15:50
Coffee Break & Poster Viewing

15:50-16:20
State-of-the-Art Lecture 2

Joong-Won Park (National Cancer Center, Goyang)

15:50-16:20
Systemic Therapies for HCC: Expanding Indications

Ghassan Abou-Alfa (Memorial Sloan Kettering Cancer Center, New York)

07:40-08:20
Breakfast Symposium 1 [Daewoong] Invitation ->

08:30-10:00

Parallel Session 1. From Bench to Bedside and Beyond

Michiie Sakamoto (Keio Univ., Tokyo), Irene Oi-Lin Ng (The Univ. of Hong Kong, Hong Kong), Do Young Kim (Yonsei Univ., Seoul)

08:30-08:50
Deciphering the Immune and Vascular Microenvironment of HCC

Michiie Sakamoto (Keio Univ., Tokyo)

08:50-09:10
Molecular Landscape of Liver Cancer and Its Clinical Implications

Xin Wei Wang (National Cancer Institute, Bethesda)

09:10-09:30
Charting Cancer Cell Plasticity in HCC with Multi-Omic Data

Stephanie Ma (The Univ. of Hong Kong, Hong Kong)

09:30-09:50
Spatial Heterogeneity and Immune Evasion Mechanism of Circulating Tumor Cells in HCC

Xin-Rong Yang (Fudan Univ, Shanghai)

09:50-10:00
Discussion

10:00-10:10
Coffee Break

10:10-10:20
Opening Ceremony

10:20-10:50
State-of-the-Art Lecture 1

Takamichi Murakami (Kobe Univ., Kobe)

10:20-10:50
When We Should Consider the Biopsy for Diagnosis, Subtyping, and Prognostication of Primary Liver Cancer: Radiologist’s Perspective

Kathryn J. Fowler (Univ. of California San Diego, San Diego)

11:00-12:30

Parallel Session 2. APPLE-KLCA Joint Symposium: Virus and HCC

Sheng-Long Ye (Fudan Univ., Shanghai), Kwang Cheol Koh (Sungkyunkwan Univ., Changwon), Young-Suk Lim (Univ. of Ulsan, Seoul)

11:00-11:20
Prevention of HBV-Related HCC: Antiviral Therapy

Young-Suk Lim (Univ. of Ulsan, Seoul)

11:20-11:40
Balancing the Risk and Benefit of Long-Term Antiviral Therapy for HBV

Wai-Kay Seto (The Univ. of Hong Kong, Hong Kong)

11:40-12:00
Latest Update of Direct-Acting Antiviral Treatment for HCV

Eiichi Ogawa (Kyushu Univ., Fukuoka)

12:00-12:20
Impact of Direct-Acting Antiviral Therapy on HCC: Occurrence, Recurrence, and Prognosis

Hyung Joon Yim (Korea Univ., Ansan)

12:20-12:30
Discussion

12:30-13:30
Luncheon Symposium 2 [Yuhan] Invitation ->

13:30-14:00
Presidential Lecture

Kyung-Suk Suh (Seoul National Univ., Seoul)

13:30-14:00
Evolution of APPLE and Liver Cancer Management

Norihiro Kokudo (National Center for Global Health and Medicine, Tokyo)

14:00-15:30

Parallel Session 3. Debatable Topics in HCC

Masayuki Kurosaki (Musashino Red Cross Hospital, Tokyo), Linda Wong (Univ. of Hawaii, Honolulu), Myeong-Jin Kim (Yonsei Univ., Seoul)

14:00-14:20
The Era of Diversity: Does Conventional TACE Still Work?

Jin Wook Chung (Seoul National Univ., Seoul)

14:20-14:40
Technical Issues in TACE: Focusing on Korean Recommendations

In Joon Lee (National Cancer Center, Goyang)

14:40-15:00
Role of Surgical Resection for HCC with Portal Vein Tumor Thrombosis

Ying-Hong Shi (Fudan Univ., Shanghai)

15:00-15:20
Integration of Systemic and Locoregional Therapy in HCC

Joong-Won Park (National Cancer Center, Goyang)

15:20-15:30
Discussion

15:30-15:50
Coffee Break & Poster Viewing

15:50-16:20
State-of-the-Art Lecture 2

Joong-Won Park (National Cancer Center, Goyang)

15:50-16:20
Systemic Therapies for HCC: Expanding Indications

Ghassan Abou-Alfa (Memorial Sloan Kettering Cancer Center, New York)

16:20-17:50

Session 4. Tumor Board: Multidisciplinary Approach

Kyung-Suk Suh (Seoul National Univ., Seoul), Han Chu Lee (Univ. of Ulsan, Seoul)

16:20-16:40
Case 1

Su Jong Yu (Seoul National Univ., Seoul)

16:40-17:00
Case 2

Su Jong Yu (Seoul National Univ., Seoul)

17:00-17:20
Case 3

Su Jong Yu (Seoul National Univ., Seoul)

17:20-17:40
Case 4

Su Jong Yu (Seoul National Univ., Seoul)

17:40-17:50
Discussant: Joong-Won Park (National Cancer Center, Goyang), Thomas Yau (The Univ. of Hong Kong, Hong Kong),
Jinsil Seong (Yonsei Univ., Seoul), Pierce Chow (National Cancer Centre Singapore, Singapore),
Edward Kim (Icahn School of Medicine at Mount Sinai, New York)

Early Morning Workshop [Surgery, Local Ablation, TARE, Systemic Therapy, and Radiation Oncology]

07:20-08:20

Changes in Surgical Strategy for HCC according to Tumor Biology

Hee Chul Yu (Jeonbuk National Univ., Jeonju), Yo-ichi Yamashita (Aso Iizuka Hospital, Fukuoka)

07:20-07:40
Changes in Resection Concepts Based on the Microvascular Invasion for Early HCC

Yo-ichi Yamashita (Aso Iizuka Hospital, Fukuoka)

07:40-08:00
Liver Transplantation Strategy according to Tumor Biology

Young Rok Choi (Seoul National Univ., Seoul)

08:00-08:20
Discussants
Kenneth Siu Ho Chok (The Univ. of Hong Kong, Hong Kong)
Jong Yun Won (Yonsei Univ., Seoul)
Dong-Sik Kim (Korea Univ., Seoul)
Kwang-Woong Lee (Seoul National Univ., Seoul)

Early Morning Workshop [Surgery, Local Ablation, TARE, Systemic Therapy, and Radiation Oncology]

07:20-08:20

Radiologic Assessment of Response to Locoregional Treatment for HCC

Kathryn J. Fowler (Univ. of California San Diego, San Diego), Jeong Min Lee (Seoul National Univ., Seoul)

07:20-07:40
LI-RADS Treatment Tesponse Algorithm

Kathryn J. Fowler (Univ. of California San Diego, San Diego)

07:40-08:00
Novel Imaging Technique for HCC Response Evaluation

Ijin Joo (Seoul National Univ., Seoul)

08:00-08:20
Discussants
Joon-Il Choi (The Catholic Univ. of Korea, Seoul)
Byoung Kuk Jang (Keimyung Univ., Daegu)
Soyeon Kim (Univ. of Ulsan, Seoul)
Dong Hyun Sinn (Sungkyunkwan Univ., Seoul)

Early Morning Workshop [Surgery, Local Ablation, TARE, Systemic Therapy, and Radiation Oncology]

07:20-08:20

Systemic Therapy: Case Presentation

Ghassan Abou-Alfa (Memorial Sloan Kettering Cancer Center, New York), Jae Young Jang (Soonchunhyang Univ., Seoul)

07:20-07:40
Management of Adverse Events in Patients Receiving Immunotherapy (Case Sharing)

Jaekyung Cheon (CHA Univ., Seongnam)

07:40-08:00
Management of Adverse Events in Patients Receiving TKI (Case Sharing)

Hye Won Lee (Yonsei Univ., Seoul)

08:00-08:20
Discussants
Thomas Yau (The Univ. of Hong Kong, Hong Kong)
Stephen Lam Chan (The Chinese Univ. of Hong Kong, Hong Kong)
Baek-Yeol Ryoo (Univ. of Ulsan, Seoul)
Jeong Won Jang (The Catholic Univ. of Korea, Seoul)

12:30-13:30
Luncheon Symposium 3 [Boston Scientific]

07:40-08:20
Breakfast Symposium 2 [Roche Diagnostics] Invitation ->

12:30-13:30
Luncheon Symposium 4 [Eisai] Invitation ->

16:20-17:20
Oral Poster Session