APPLE 2023

DAILY PROGRAM

ROOM AB (Grand Ballroom 1+2)
ROOM C (Grand Ballroom 3)
ROOM D (Orchid)

ROOM 1 (Iris)
ROOM 2 (Camelia)
ROOM 3 (Lotus)

08:30-10:00

Session 5. Optimal Strategy for Systemic Therapy for Advanced HCC

Andrew X. Zhu (I-Mab Biopharma, Shanghai), Ann-Lii Cheng (National Taiwan Univ., Taipei), Si Hyun Bae (The Catholic Univ. of Korea, Seoul)

08:30-08:50
Optimal First-Line Therapy for HCC

Baek-Yeol Ryoo (Univ. of Ulsan, Seoul)

08:50-09:10
Optimal Subsequent Option after First-Line Immuno-Oncology Therapy in Advanced HCC

Andrew Zhu (I-Mab Biopharma, Shanghai)

09:10-09:30
Optimal Subsequent Option after First-Line Multi-Kinase Inhibitor Therapy for Advanced HCC

Chih-Hung Hsu (National Taiwan Univ., Taipei)

09:30-09:50
Matching the Right Agents with the Right Patients for the Management of HCC: Biomarkers for Systemic Therapy

Thomas Yau (The Univ. of Hong Kong, Hong Kong)

09:50-10:00
Discussion

10:00-10:20
Coffee Break & Poster Viewing

10:20-11:00
State-of-the-Art Lecture 3

Kwang-Hyub Han (CHA Univ., Seoul)

10:20-11:00
Update on the Molecular-Pathological Features of HCC and Cholangiocarcinoma

Young Nyun Park (Yonsei Univ., Seoul)

11:00-12:30

Session 6. A Deep Dive into the Era of Immuno-Oncology

Richard S. Finn (Univ. of California Los Angeles, LA), Won Young Tak (Kyungpook National Univ., Daegu), Ho-Yeong Lim (Sungkyunkwan Univ., Seoul)

11:00-11:20
Trajectory of Immune Evolution and Mechanism of Response to Immunotherapy in HCC

Valerie Chew (Duke-NUS Medical School, Singapore)

11:20-11:40
Rechallenging of Immuno-Oncology Treatment after Complications: Can It Be Done Safely?

Stephen Lam Chan (The Chinese Univ. of Hong Kong, Hong Kong)

11:40-12:00
Neo-Adjuvant or Adjuvant Immunotherapy in HCC: Where Are We Now?

Ann-Lii Cheng (National Taiwan Univ., Taipei)

12:00-12:20
Immuno-Oncology in the Treatment of HCC: Future Perspectives

Richard S. Finn (Univ. of California Los Angeles, LA)

12:20-12:30
Discussion

12:30-13:30
Luncheon Symposium 5 [Eisai] Invitation ->

13:30-15:00

Session 7. Emerging Therapy and Precision Medicine

Chiun Hsu (National Taiwan Univ., Taipei), Jung-Hwan Yoon (Seoul National Univ., Seoul), Moon Seok Choi (Sungkyunkwan Univ., Seoul)

13:30-13:50
Novel Targets in HCC

Augusto Villanueva (Icahn School of Medicine at Mount Sinai, New York)

13:50-14:10
CAR T-Cell Therapy for the Solid Tumors Including HCC: Prospects and Challenges

Kyungho Choi (Seoul National Univ. Seoul)

14:10-14:30
Promising Agents in Early Clinical Trials for Unresectable HCC

Masafumi Ikeda (National Cancer Center Hospital East, Kashiwa)

14:30-14:50
Radiation Therapy in HCC: Future Perspectives

Jinsil Seong (Yonsei Univ., Seoul)

14:50-15:00
Discussion

15:00-15:20
Coffee Break & Poster Viewing

15:20-16:50

Session 8. Recent Updates of Intrahepatic Cholangiocarcinoma

Christopher Crane (Memorial Sloan Kettering Cancer Center, New York), Kyung Sik Kim (Yonsei Univ., Seoul), Min-hee Ryu (Univ. of Ulsan, Seoul)

15:20-15:40
Pathological and Molecular Features of Intrahepatic Cholangiocarcinoma

Peter Schirmacher (Heidelberg Univ., Heidelberg)

15:40-16:00
Surgical Management of Intrahepatic Cholangiocarcinoma: A Comparison with HCC

Etsuro Hatano (Kyoto Univ., Kyoto)

16:00-16:20
Systemic Therapy for Intrahepatic Cholangiocarcinoma: Current and Future Perspectives

Do-Youn Oh (Seoul National Univ., Seoul)

16:20-16:40
The Importance of Local Tumor Control for Inoperable Intrahepatic Cholangiocarcinoma

Christopher Crane (Memorial Sloan Kettering Cancer Center, New York)

16:40-16:50
Discussion

16:50-17:20
Summary of APPLE 2023
Award & Closing Ceremony

07:40-08:20
Breakfast Symposium 3 [Roche] Invitation ->

08:30-10:00

Parallel Session 4. Application of Artificial Intelligence (AI) in Liver Cancer

Julien Calderaro (Henri Mondor Univ. Hospital, Créteil), Yong Han Paik (Sungkyunkwan Univ., Seoul), ‪Namkug Kim (Univ. of Ulsan, Seoul)

08:30-08:50
AI-Based Cancer Screening Using Liquid Biopsy

Eunhae Cho (GC Genome, Yongin)

08:50-09:10
Qualitative and Quantitative Imaging Biomarkers to Predict Prognosis of HCC

Seung Soo Lee (Univ. of Ulsan, Seoul)

09:10-09:30
AI-Based Pathology: A New Generation of Biomarkers for HCC

Julien Calderaro (Henri Mondor Univ. Hospital, Créteil)

09:30-09:50
Predicting HCC Risk Using Artificial Intelligence

Jeong-Hoon Lee (Seoul National Univ., Seoul)

09:50-10:00
Discussion

10:00-10:20
Coffee Break & Poster Viewing

10:20-11:00
State-of-the-Art Lecture 3

Kwang-Hyub Han (CHA Univ., Seoul)

10:20-11:00
Update on the Molecular-Pathological Features of HCC and Cholangiocarcinoma

Young Nyun Park (Yonsei Univ., Seoul)

11:00-12:30

Parallel Session 5. A New Era of Liver Transplantation Oncology

Norihiro Kokudo (National Center for Global Health and Medicine, Tokyo), Kenneth Siu Ho Chok (The Univ. of Hong Kong, Hong Kong), Young Kyoung You (The Catholic Univ. of Korea, Seoul)

11:00-11:20
Extended Criteria for Liver Transplantation in HCC

Toru Ikegami (The Jikei Univ. School of Medicine, Tokyo)

11:20-11:40
Down-Staging and Waiting Times for Liver Transplantation in Advanced HCC

Dong Jin Joo (Yonsei Univ., Seoul)

11:40-12:00
The Role of Transplantation in Combined Hepatocellular-Cholangiocarcinoma

Linda Wong (Univ. of Hawaii, Honolulu)

12:00-12:20
Multidisciplinary Approach for Post-Liver Transplantation Recurrence

Kenneth Siu Ho Chok (The Univ. of Hong Kong, Hong Kong)

12:20-12:30
Discussion

12:30-13:30
Luncheom Symposium 6 [AstraZeneca] Invitation ->

13:30-15:00

Parallel Session 6. Recent Advance of Surgical Resection for HCC: Expanding the Surgical Indication

Takumi Fukumoto (Kobe Univ., Kobe), Jae Seok Hwang (Keimyung Univ., Daegu), Shin Hwang (Univ. of Ulsan, Seoul)

13:30-13:50
Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) for Unresectable HCC

Jian Zhou (Fudan Univ., Shanghai)

13:50-14:10
Surgical Resection of Multiple HCC

Shin Hwang (Univ. of Ulsan, Seoul)

14:10-14:30
Surgical Resection for Intrahepatic and Extrahepatic Recurrent HCC

Etsuro Hatano (Kyoto Univ., Kyoto)

14:30-14:50
Laparoscopic Repeated Liver Resection for Recurrent HCC

Zenichi Morise (Fujita Health Univ., Toyoake)

14:50-15:00
Discussion

15:00-15:20
Coffee Break & Poster Viewing

15:20-16:50

Parallel Session 7. Various Classification of Liver Cancer towards Precision Medicine

Augusto Villanueva (Icahn School of Medicine at Mount Sinai, New York), Young Nyun Park (Yonsei Univ., Seoul), Joon Hyoek Lee (Sungkyunkwan Univ., Seoul)

15:20-15:40
Morphological Classification of HCC and Potential Clinical Implications

Haeryoung Kim (Seoul National Univ., Seoul)

15:40-16:00
Stratification of HCC : Cellular, Molecular and Blood-Based Biomarkers

Irene Oi-Lin Ng (The Univ. of Hong Kong, Hong Kong)

16:00-16:20
Correlation of Imaging and Molecular-Pathologic Subtypes of HCC

Jin Young Choi (Yonsei Univ., Seoul)

16:20-16:40
Biopsy for HCC: Tissue or Liquid?

Xin-Rong Yang (Fudan Univ, Shanghai)

16:40-16:50
Discussion

Early Morning Workshop [Surgery, Local Ablation, TARE, Systemic Therapy, and Radiation Oncology]

07:20-08:20

Liver Cancer Molecular Classification and Its Application

Peter Schirmacher (Heidelberg Univ., Heidelberg), Young Nyun Park (Yonsei Univ., Seoul)

07:20-07:35
The Molecular Classification of HCC and Application of AI

Julien Calderaro (Henri Mondor Univ. Hospital, Créteil)

07:35-07:50
The Immune Microenvironment of HCC and Its Implication in Immunotherapy

Michiie Sakamoto (Keio Univ., Tokyo)

07:50-08:05
The Role of Liquid Biopsy in the Prognostication of HCC

Irene Oi-Lin Ng (The Univ. of Hong Kong, Hong Kong)

08:05-08:20
The Molecular Classification of CCA and Its Application in Clinical Practice

Peter Schirmacher (Heidelberg Univ., Heidelberg)

Early Morning Workshop [Surgery, Local Ablation, TARE, Systemic Therapy, and Radiation Oncology]

07:20-08:20

TACE for HCC: Technical Recommendations of the Korea Liver Cancer Association

Jin Wook Chung (Seoul National Univ., Seoul), Edward Kim (Icahn School of Medicine at Mount Sinai, New York)

07:20-07:40
Superselective TACE Using Ethiodized Oil Emulsions and Drug-Eluting Beads in Korea

Jin Woo Choi (Seoul National Univ., Seoul)

07:40-07:55
Technical Issues of cTACE

Dongho Hyun (Sungkyunkwan Univ., Seoul)

07:55-08:10
Technical Issues of DEB-TACE

Jung Suk Oh (The Catholic Univ. of Korea, Seoul)

08:10-08:20
Discussants
Young Seok Kim (Soonchunhyang Univ., Bucheon)
Geum-Youn Gwak (Sungkyunkwan Univ., Seoul)
Jaeyoun Cheong (Ajou Univ., Suwon)
Chang Wook Kim (The Catholic Univ. of Korea, Seoul)

12:30-13:30
Luncheon Symposium 7 [Boryung]

Early Morning Workshop [Surgery, Local Ablation, TARE, Systemic Therapy, and Radiation Oncology]

07:20-08:20

Radiotherapy as the Best Option at Various Stages

Christopher Crane (Memorial Sloan Kettering Cancer Center, New York), Hee Chul Park (Sungkyunkwan Univ., Seoul)

07:20-07:40
Radiotherapy in Early HCC

Tae Hyun Kim (National Cancer Center, Goyang)

07:40-08:00
Ablative Radiation for Advanced HCC

Christopher Crane (Memorial Sloan Kettering Cancer Center, New York)

08:00-08:20
Discussants
Sang Min Yoon (Univ. of Ulsan, Seoul)
Jason Chia-Hsien Cheng (National Taiwan Univ., Taipei)
Seung Up Kim(Yonsei Univ., Seoul)
Ji Hoon Kim (Korea Univ., Seoul)

07:20-08:20
Meet the Expert Prof. Abou-Alfa

12:30-13:30
Luncheon Symposium 7 [Bayer] Invitation ->